We worked with a world-class team of formulation experts, doctors, and PharmDs in the development of our formulation. Our goal was to make sure we're offering the single best microplastic detox formulation on the market, and we strongly believe we achieved that goal!

Refer to the "Science" section of our website for more information on our formulation process, as well as in-depth commentary on all ingredients and why they're included.

We have a world-class team of formulation experts, medical experts, and pharmacists that lead our formulation process, and all of our manufacturing happens in a GMP-certified facility. The team and facility where our products are formulated and manufactured are regulated by the Food and Drug Administration (FDA) pursuant to the requirements of the Federal Food, Drug and Cosmetic Act (FD & C Act) and the Fair Packaging Act (FPLA) and other related federal and state laws.

All of our ingredients are tested prior to manufacturing to verify their purity and lack of any unintended microbes and to ensure there are no heavy metals. Our manufacturing team prepares a Certificate of Analysis (COA) for each manufacturing run performed.

We generally recommend that new customers use Daily Detox supplementation for at least 60 days in order to realize full benefits, but results may vary from person to person!

That said, given the prevalence of microplastics in our world today (including in most drinking water and many everyday use products), it can be difficult to avoid these toxins entirely. As such, it can be valuable to stay on our Daily Detox supplementation protocol over a longer time horizon to ensure you're keeping your body free of these toxins over the long-run, even if you're unable to avoid them entirely in your everyday life.

The dosages were determined through a combination of scientific research, including preclinical studies, clinical trials, and reviews of existing literature. 

Preclinical Studies

1. In Vitro and Animal Studies: Researchers may start with laboratory and animal studies to explore the effects of these substances on detoxification pathways, such as liver function or the excretion of toxins.

Clinical Trials

1. Phase I Trials: Initial human trials would focus on safety and pharmacokinetics, determining how the body processes the substances.
2. Phase II Trials: These trials would assess the efficacy of the supplements for detoxification at various dosages.
3. Phase III Trials: Larger trials would further refine the dosage by comparing different amounts to find the optimal balance between efficacy and safety.

Systematic Reviews and Meta-Analyses

1. Data Aggregation: A compilation of data from multiple studies to determine the most effective dosages.

Expert Consensus

Professional Guidelines: Medical and scientific organizations provided dosage recommendations based on a consensus of expert opinion and clinical evidence.

1. Regulatory Bodies
2. Recommended Daily Allowances (RDAs): For some nutrients like Vitamin C, regulatory bodies provided RDAs or upper intake levels.

There are no well-documented specific supplements to avoid while taking Daily Detox. However, it's crucial to monitor total intake and potential overlapping effects with similar supplements.

Broad Recommendations

1. Avoid High Doses: Taking multiple supplements that serve similar functions or affect similar pathways can increase the risk of adverse effects due to cumulative high doses.
2. Be Cautious with Herbal Supplements: Herbal supplements can have potent effects and interact with other supplements in unpredictable ways. For example, St. John's Wort can affect the metabolism of many substances.
3. Consult Healthcare Providers: Before starting any new supplement regimen, especially when combining multiple supplements, consult with a healthcare provider or a pharmacist to review potential interactions and contraindications based on your specific health situation and medications.

Ultimately, specific interactions can depend on individual health conditions, dosages, and the presence of other substances, but here are some general considerations:

L-Carnitine

1. Acetyl-L-Carnitine: Taking L-Carnitine with Acetyl-L-Carnitine may not be harmful, but it's important to consider the total carnitine dosage to avoid potential side effects like nausea or diarrhea.

Quercetin

1. Other Flavonoids: While not necessarily harmful, taking Quercetin with other flavonoid supplements (like green tea extract, resveratrol) could potentiate effects, warranting caution with dosing.

Vitamin C

1. Iron Supplements: Vitamin C can increase iron absorption, which is beneficial in some cases but could be problematic for individuals with conditions like hemochromatosis.
2. Other Antioxidants: High doses of Vitamin C taken with other antioxidants (e.g., Vitamin E, beta-carotene) might theoretically reduce the effectiveness of one another due to antioxidant recycling mechanisms.

Calcium D-glucarate

1. Other Calcium Supplements: Combining Calcium D-glucarate with other calcium supplements could lead to excessive calcium intake, potentially increasing the risk of hypercalcemia.

L-Cysteine

N-acetylcysteine (NAC): As a derivative of L-Cysteine, taking NAC alongside L-Cysteine could increase the risk of side effects like nausea, vomiting, or diarrhea.

1. L-Glutamic Acid, L-Glycine, Lycopene